Boosting FGF21 signaling to treat pancreatitis

INDICATION: Pancreatitis

FGF21 replacement therapy or inhibition of PERK-mediated FGF21 repression could treat pancreatitis. Pancreatic levels of FGF21 protein were lower in 52 patients with acute or chronic pancreatitis than in 14 healthy individuals. In three mouse models of pancreatitis, recombinant FGF21 lowered disease severity scores and reduced signs of disease including levels of amylase and pancreatic myeloperoxidase activity in plasma, as well as pancreatic edema, inflammation and necrosis. A PERK inhibitor tool compound led to similar results in one of the models...