IL1RL1 in Treg cells as a lung cancer target

INDICATION: Lung cancer

Inhibiting IL1RL1, which signals in response to IL-33 binding, in Treg cells could treat lung cancer. In single-cell RNA sequencing analyses of CD4⁺ T cells from the lymph nodes and lungs of mice modeling lung cancer, IL1RL1 expression was higher in T reg cells than in other CD4⁺ cell types. In the mice, IL1RL1 knockout in Tregs reduced tumor growth and increased the number of tumor-infiltrating CD8⁺ T cells...