Disney lab uncovers another RNA-binding small molecule for triple-negative breast cancer

Matthew Disney is attacking triple-negative breast cancer again with the latest iteration of his RNA-binding small molecule technology, which marries the concept with targeted RNA degradation to eliminate disease-causing RNA segments.

In a paper published in the Proceedings of the National Academy of Sciences (PNAS) on Jan. 20, Disney and colleagues showed that a small molecule construct designed to degrade the precursor of oncogenic miR-21 prevented TNBC metastasis in mice...