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CPSF3 emerges as new synthetic lethality target in AML and sarcoma

NIBR identifies CPSF3 as novel synthetic lethality target in subsets of AML, sarcoma

A team led by the Novartis Institutes for BioMedical Research identified CPSF3, a pre-mRNA processing endonuclease, as a novel synthetic lethality target for a subset of AML and sarcomas.

The premise of synthetic lethality is that genomic or pharmacologically induced defects that are tolerated individually become

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