BioCentury
ARTICLE | Targets & Mechanisms

Controlling T cells via epigenetics

INSERM team proposes new autoimmune, immunodeficiency T cell targets in epigenetic pathway

December 20, 2019 2:57 AM UTC
Updated on Dec 20, 2019 at 1:54 PM UTC

An international academic team has discovered an epigenetic pathway that regulates CD4+ T cell differentiation and activity, and could yield new therapeutic targets for autoimmunity.

As drug developers seek the next generation of targeted therapies for autoimmune disease, one hope is that a better understanding of the genetic and molecular determinants of immune cell identity will lead to new therapeutic approaches (see “Rethinking Definitions Of Autoimmune Disease”)...