BioCentury
ARTICLE | Targets & Mechanisms

A view of immune reprogramming from ASH

ASH abstracts reveal new mechanisms and consequences of immune cell repolarization in hematology

December 6, 2019 3:51 AM UTC
Updated on Dec 6, 2019 at 4:06 AM UTC

ASH presentations on immune reprogramming point to new targets and mechanisms that control macrophage and T cell phenotype switching, and highlight the phenomenon's translational relevance in diseases beyond solid tumors.

Strategies to convert immunosuppressive macrophage and T cell subsets into proinflammatory cells are gaining momentum as a way to simultaneously release the brakes and rev up the gas for antitumor immunity (see "Flipping the Switch in Immuno-oncology")...