Dopamine receptor agonism for pulmonary fibrosis, liver fibrosis

INDICATION: Pulmonary fibrosis; liver fibrosis

Agonism of the dopamine receptor DRD1 could treat pulmonary and liver fibrosis. In cultures of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis (IPF), a DRD1 agonist tool compound decreased proliferation, accumulation of collagen and fibronectin, and markers of contractile myofibroblasts, all hallmarks of the disease. In mouse models of bleomycin-induced pulmonary fibrosis and bile duct ligation-induced cholestatic liver fibrosis, the DRD1 agonist reduced histological fibrosis and collagen deposition in the respective organs...