New roles for HDACs in the cytoplasm and muscle disorders
NIBR shows HDACs do more than deacetylate histones, suggests HDAC4 inhibition for muscle diseases
While HDACs are known for their epigenetic function, NIBR researchers have discovered cytoplasmic HDAC4 substrates involved in muscle physiology. The findings suggest blocking HDAC4 deacetylation activity could treat muscle atrophy and other musculoskeletal disorders.
HDACs are named for their ability to modify