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Cedilla: degrading proteins by modulating protein stability

How Cedilla harnesses native destabilization mechanisms to degrade proteins

While most protein degradation companies are developing bifunctional molecules that directly induce ubiquitin-mediated degradation, Cedilla is taking a different approach with monovalent small molecules that trigger a broader range of degradation mechanisms.

“The concept of being able to go after it not with the bivalents or bifunctionals but rather with a monovalent program or monovalent compound just seemed incredibly compelling to us,” said Neil

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