Nov. 7 Preclinical Quick Takes: NIH drafts policy requiring more data sharing; plus Unum, Mission-BioLegend, DCprime and more

NIH pitches policy for greater sharing of data
NIH has published a draft of the NIH Policy for Data Management and Sharing to promote wider sharing of data and results generated from NIH-funded grant work with the public and other researchers. Existing policy mandates NIH-funded researchers submit peer-reviewed manuscripts to PubMed Central, and sets expectations regarding the sharing of genomic and clinical trial data. The new policy would require additional clinical data be made publicly available. Funding recipients would need to submit a data management and sharing plan prior to initiating research, and the shared data “should be made accessible in a timely manner for use by the research community and the broader public.”

Unum reports preclinical data for one cell therapy, halts dosing of another
Unum Therapeutics Inc. (NASDAQ:UMRX) presented the first preclinical data for engineered CAR Ts from its BOXR platform at the Society for Immunotherapy of Cancer (SITC) meeting in Fort Washington, Md. BOXR1030, which expresses a GPC3-targeting CAR plus the mitochondrial enzyme GOT2 to prevent T cell dysfunction and exhaustion, had better antitumor activity in xenograft mouse models of solid tumor models than standard CAR T and led to complete tumor regression. ...