New cereblon substrates linked to thalidomide teratogenicity
New drug-dependent cereblon substrates linked to thalidomide teratogenicity
A Celgene-funded study from Tokyo Medical University and the University of Milan has identified two new thalidomide-dependent CRBN substrates that could be applied to screens for new, safer thalidomide derivatives.
Thalidomide and its analogs, collectively called imids, cause a range of teratogenic effects, including limb deformities, ear malformation and heart defects. Thalidomide was banned