New cereblon substrates linked to thalidomide teratogenicity

New drug-dependent cereblon substrates linked to thalidomide teratogenicity

A Celgene-funded study from Tokyo Medical University and the University of Milan has identified two new thalidomide-dependent CRBN substrates that could be applied to screens for new, safer thalidomide derivatives.

Thalidomide and its analogs, collectively called imids, cause a range of teratogenic effects, including limb deformities, ear malformation and heart defects.

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