BioCentury

GCCR inhibition could treat Ewing sarcoma

October 31, 2019 8:27 PM UTC

INDICATION: Bone cancer

A team from the Weizmann Institute showed that GCCR inhibitors could be repurposed to treat Ewing sarcoma. The GCCR inhibitor Mifegyne mifepristone decreased proliferation in cultures of human Ewing sarcoma cell lines. Mifegyne also reduced tumor growth in three mouse models of the disease, and decreased the number of lung nodules in mice with metastatic Ewing sarcoma...

BCIQ Company Profiles

Weizmann Institute of Science

BCIQ Target Profiles

Glucocorticoid receptor (GCCR)