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KRAS inhibitor combinations for improved therapeutic efficacy

DISEASE CATEGORY: Cancer

INDICATION: Lung cancer, pancreatic cancer

UCSF’s Kevan Shokat and colleagues have identified two sets of genes for which inhibition could improve the efficacy of KRAS G12C inhibitors. Through a CRISPR-based screen in human lung and pancreatic cancer cells treated with a KRAS G12C inhibitor tool compound for genes

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