TNFR2 agonism for neuropathic pain

INDICATION: Pain

TNFR2 agonism could help treat neuropathic pain. TNFR2 activity has implicated in early development of neuropathic pain as well as the promotion of anti-inflammatory responses thought to suppress development of neuropathic pain. In mice with chronic constriction injury-induced neuropathic pain, a TNFR2 agonist tool compound reduced mechanical allodynia, cold allodynia and thermal hyperalgesia and decreased levels of inflammatory markers in the sciatic nerve...