BioCentury
ARTICLE | Translation in Brief

What Excision needs to demonstrate before bringing CRISPR-HIV therapy to clinic

With mouse data for a functional HIV cure in hand, Excision needs to prove itself in monkeys before entering the clinic next year

July 18, 2019 9:52 PM UTC

After the scientific team behind Excision showed that CRISPR can excise viral HIV DNA from mice genomes, NIAID Director Anthony Fauci cautioned that the therapy will need to prove itself on at least three fronts in non-human primates before it should be tested in humans.

In a Nature Communications paper published July 2, University of Nebraska and Temple University researchers showed that combining long-acting antiretroviral therapy with CRISPR led to a functional HIV cure in eight of 23 mice (see Distillery)...