Inhibiting EZH2 for myeloma-associated bone loss

INDICATION: Bone repair

Inhibiting EZH2 could help repair myeloma-associated bone loss. Among 20 myeloma patients in remission, levels of EZH2 mRNA in bone marrow adipocytes, which are associated with bone loss, correlated with the frequency of osteolytic bone lesions. In mice in myeloma remission that also exhibited bone loss, knockout of EZH2 in adipocytes restored bone volume and reduced bone surface erosion and numbers of osteolytic bone lesions in femurs...