Inhibiting EZH2 for colitis and colitis-associated colorectal cancer

INDICATION: Colitis; colorectal cancer

Inhibiting EZH2 could help treat colitis and colitis-associated colorectal cancer. The EZH2 inhibitor GSK2816126 or a tool compound EZH2 inhibitor increased survival and colon length, which is shortened in the disease, in a mouse model of colitis. The compounds also reduced clinical and histological disease scores and colon levels of proinflammatory cytokines. In mice with colitis-associated colorectal cancer the tool compound delayed tumor onset...