ARTICLE | Translation in Brief
Binding the extracellular matrix to target brain tissue
Binding the extracellular matrix exposed by disrupted BBB to target brain tissue
June 7, 2019 1:50 AM UTC
Attaching biologics to an antigen receptor derived from a fish that preferentially binds the brain's extracellular matrix could enable targeted drug delivery to the CNS.
A University of Wisconsin-Madison team found that lamprey-derived immune molecules called variable lymphocyte receptors (VLRs) could target brain tissue made accessible by a leaky blood-brain barrier while avoiding systemic toxicity...