Inhibiting CB1 for alcohol addiction

INDICATION: Addiction

Studies in mice suggest inhibiting CB1 could help treat alcohol addiction. In a mouse model of alcohol addiction, an shRNA targeting CB1 reduced alcohol preference compared with a scrambled shRNA. Also in the model, the CB1 inverse agonist JD-5037 reduced alcohol preference and intake compared with vehicle. Next steps could include testing other CB1 inhibitors in models of alcohol addiction. ...