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ARTICLE | Preclinical News

Cyclerion's sGC activation could work for NASH

May 14, 2019 12:00 AM UTC

With new preclinical data in hand, Ironwood-spinout Cyclerion is making the case for extending its lead sGC stimulator praliciguat into NASH.

Cyclerion Therapeutics Inc. (NASDAQ:CYCN) completed its spinout from Ironwood Pharmaceuticals Inc. (NASDAQ:IRWD) in April with a pipeline of five soluble guanylate cyclase (sGC) programs, including praliciguat, a systemic sGC stimulator in Phase II trials to treat diabetic nephropathy and heart failure preserved ejection fraction (HFpEF) (see "Ironwood Spinout Cyclerion Planning $175M Private Placement")...