BioCentury
ARTICLE | Distillery Therapeutics

PARG inhibition for ovarian cancer

May 6, 2019 7:25 PM UTC

INDICATION: Ovarian cancer

Cell culture experiments suggest inhibiting PARG alone or in combination with Chk1 inhibitors could help treat ovarian cancer. In three human ovarian cancer cell lines, a tool compound PARG inhibitor decreased colony formation compared with vehicle. In three more human ovarian cancer cell lines, the PARG inhibitor plus a tool compound Chk1 inhibitor synergistically decreased proliferation and increased apoptosis compared with either agent alone. In tumor cells from four ovarian cancer patients, the inhibitor combination decreased proliferation and colony formation. Next steps in collaboration with Ideaya Biosciences Inc. include developing undisclosed PARG inhibitors for an undisclosed indication...