Tumors release PD-L1 exosomes to evade antitumor immunity

UCSF researchers have found a clue to anti-PD-L1 resistance in exosomes released by tumors, and suggested blocking exosome release as a solution.

In a Cell paper published Thursday, the University of California San Francisco team homed in on prostate cancer, an indication where PD-1/PD-L1 drugs are ineffective, though the implications could extend to other cancers where the checkpoint inhibitor response rates are typically 30% or lower...