Kronos co-founder, MIT team discover compound that indirectly blocks MYC

An MIT team led by Kronos co-founder Angela Koehler has discovered a small molecule that prevents MYC, an oncogene considered undruggable, from driving gene expression by locking up its binding partner MAX.

The transcription factor MAX can form dimers with itself or other transcription factors including MYC. Binding and stabilizing the MAX dimer shifts MAX away from binding with MYC, thereby blocking MYC-driven transcription...