BioCentury
ARTICLE | Preclinical News

Repurposing an HIV target could aid brain injury recovery

February 21, 2019 9:58 PM UTC

Extending CCR5 inhibition beyond treating HIV/AIDS, UCLA researchers showed that blocking CCR5 could promote recovery from stroke and traumatic brain injury (TBI).

CC chemokine receptor 5 (CCR5; CD195) is well known for its role in enabling HIV entry into immune cells, but studies have also shown that blocking the receptor can enhance learning, memory and neuronal plasticity -- processes mediated by mechanisms also involved in brain injury recovery...