ARTICLE | Emerging Company Profile
Refuge: Receptive CAR checkpoints
How Refuge is using CRISPR to suppress checkpoint genes in CAR T cells
February 21, 2019 8:16 PM UTC
Refuge Biotechnologies Inc. aims to make CAR T cells more potent by suppressing their checkpoint genes and is using a form of CRISPR that knocks the genes down instead of out to improve safety.
CEO Bing Wang told BioCentury that like endogenous T cells, CAR T cell therapies also express checkpoint proteins that can limit their anti-tumor activity. ...
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