Cancer; gastrointestinal; inflammation

Mouse studies suggest inhibiting SPR could help treat colitis and asthma, and its biosynthetic product THB could help treat breast cancer. In a xenograft mouse model of breast cancer, THB decreased tumor growth and increased T cell numbers in tumors compared with vehicle. In a mouse model of colitis, a tool compound SPR inhibitor decreased T cell infiltration in the intestine and scores of colitis severity. In a mouse model of ovalbumin-induced asthma, the SPR inhibitor decreased numbers of immune cells in bronchoalveolar lavage. Next steps could include testing THB in additional models of breast cancer and SPR inhibitors in additional models of colitis and asthma...