Infectious disease

Non-human primate studies suggest soluble HIV env trimer given in combination with a saponin-based adjuvant could help prevent HIV infection. In macaques challenged with HIV, immunization with soluble HIV env trimer plus the saponin-based adjuvant decreased peak viremia and increased serum titers of neutralizing antibodies compared with no treatment and prevented infection for a median of 10 subsequent challenges. Next steps could include toxicity studies of the combination...