ARTICLE | Translation in Brief
Sorting out exosomes
Researchers show UBL3 sorts oncogenic Ras to exosomes for export
October 19, 2018 12:55 AM UTC
A team of Japanese researchers have identified UBL3 as a new therapeutic target for cancers and neurodegenerative diseases that spread via the exosome-based intercellular communication system.
The ubiquitin system sorts proteins for cellular export via small extracellular vesicles (EVs) such as exosomes, which are excreted to traffic the proteins from one cell to another. Tumor progression and neurodegenerative diseases have been linked to intercellular protein delivery...
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