ARTICLE | Distillery Therapeutics
Infectious disease
October 11, 2018 7:27 PM UTC
Mouse studies suggest TLR3 inhibitors could help treat herpes simplex virus type 1 (HSV-1)-induced encephalitis. In a mouse model of HSV-1 encephalitis, an anti-TLR3 antibody decreased CNS viral levels and increased survival compared with control IgG. Next steps could include testing other TLR3 inhibitors in models of HSV-1 encephalitis.
Johnson & Johnson has CNTO 3157 (CNTO3157, JNJ-42915925, PRV-300), an anti-TLR3 mAb, in Phase II testing for asthma and Phase I testing for inflammation, and in Phase I testing for inflammatory bowel disease (IBD) with partners with MorphoSys AG and Provention Bio Inc...
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