BioCentury
ARTICLE | Emerging Company Profile

Bugs on film

How Scioto is using biofilm formulation to boost colonization of gut probiotics

August 23, 2018 6:36 PM UTC

Microbiome company Scioto Biosciences Inc. is turning a longstanding enemy of antibiotics developers -- biofilms -- into a delivery vehicle for probiotics.

The company expects its lead candidate SB-121, an orally delivered biofilm formulation of Lactobacillus reuteri, to be useful across a swath of diseases where patients are at risk of developing intestinal inflammation and leakage. Its lead indication is necrotizing enterocolitis, a rare and sometimes fatal disease that occurs in premature babies with low birth weights...