Inhibiting MMP2 reverses leptin resistance associated with obesity

University of California San Diego researchers and colleagues showed that inhibiting cleavage of leptin receptor (LEPR; CD295) by matrix metalloproteinase 2 (MMP2) could help prevent leptin resistance and treat obesity.

Obesity is associated with high circulating concentrations of leptin, a hormone that signals satiety to the brain, but reduced LEPR signaling (known as leptin resistance). However, the molecular mechanisms leading to leptin resistance have not been fully characterized...