Poisoning the stromal chalice

Why an ADC could be the right modality to kill tumors by targeting their stroma

A study published in the Journal of Clinical Investigation suggests antibody-drug conjugates targeting the tumor stroma could treat cancers by co-opting a stromal mechanism to feed cytotoxic drugs to the surrounding tumor cells.

Tumor-associated stroma, which comprises fibroblasts and connective tissue components, is a non-malignant feature of all solid tumors that supports tumor growth and can physically protect tumor cells from exposure to therapies.

The JCI study, led by

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