Poisoning the stromal chalice
Why an ADC could be the right modality to kill tumors by targeting their stroma
A study published in the Journal of Clinical Investigation suggests antibody-drug conjugates targeting the tumor stroma could treat cancers by co-opting a stromal mechanism to feed cytotoxic drugs to the surrounding tumor cells.
Tumor-associated stroma, which comprises fibroblasts and connective tissue components, is a non-malignant feature of all solid tumors that supports tumor growth and can physically protect tumor cells from exposure to therapies.
The JCI study, led by