BioCentury
ARTICLE | Tools & Techniques

Bundled inheritance

How a new take on GWAS data is shedding light on schizophrenia and migraine

May 31, 2018 9:46 PM UTC

Two new studies showcase how researchers are gleaning more from GWAS by combining risk factors rather than looking at the risks from individual mutations. The results could add numbers to the contribution of nature vs. nurture for diseases like schizophrenia and migraine.

A key feature of the debate around the utility of genome-wide association studies (GWAS) is that individual hits often have effect sizes that are too small to meaningfully unravel disease biology or identify drug targets...