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Click chemistry HATRIC

ETH is using click chemistry to find all cell surface binding proteins for any given ligand

May 24, 2018 5:46 PM UTC

Researchers at ETH Zurich have developed a click chemistry-based screening method that can identify all cell surface proteins that bind a ligand. The hope is that surface proteins exclusively present on select cell types will provide new leads for targeted drug delivery.

The method, published in Nature Communications in April, uses a tri-functional compound dubbed HATRIC that can be conjugated to any ligand and incubated with live cells to identify cell surface proteins the ligand interacts with. ...