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ARTICLE | Emerging Company Profile

Engine power

Engine is combining a genetic screen with machine learning to discover targets

April 19, 2018 7:17 PM UTC

Engine Biosciences Pte. Ltd. is marrying a CRISPR-Cas9 genetic perturbation screen with machine learning to delineate how combinations of genes contribute to disease phenotypes and thereby identify novel targets for a range of diseases.

The company, which launched in 2014, holds exclusive rights to combinatorial CRISPR screening technology from the lab of Timothy Lu that was described in a 2016 paper in the Proceedings of the National Academy of Sciences. Lu is an associate professor of biological engineering, electrical engineering and computer science at the Massachusetts Institute of Technology, ...