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ARTICLE | Clinical News

Patient deaths reported in Tecentriq, Cotellic combo arm of Phase II mCRC trial

April 13, 2018 1:37 PM UTC

Roche (SIX:ROG; OTCQX:RHHBY) said it temporarily halted recruitment in the Phase II MODUL trial to treat metastatic colorectal cancer (mCRC) following four deaths, including a case of treatment-related cardiogenic shock, in a cohort of patients receiving Tecentriq atezolizumab in combination with Cotellic cobimetinib.

The open-label, international MODUL trial is evaluating combinations of anticancer agents as maintenance treatment of first-line mCRC in biomarker-selected populations following induction treatment with FOLFOX chemotherapy and Avastin bevacizumab. The cohort evaluating Tecentriq plus Cotellic enrolled HER2-negative, microsatellite instability-high (MSI-H) patients; HER2-negative, microsatellite-stable, wild-type BRAF patients; and HER2-negative, microsatellite-stable, BRAF-mutant, K-Ras (KRAS)-mutant patients...