Strong-arming drug delivery

In a Nature Communications study, a Harvard team developed extracellular vesicles that can deliver a variety of macromolecular cargo inside target cells or tissues, paving the way for therapeutics against traditionally intractable intracellular targets.

Previously, a group led by Quan Lu, an associate professor of environmental genetics and pathophysiology at Harvard T. H. Chan School of Public Health, showed that arrestin domain containing 1 (ARRDC1) catalyzes the budding of vesicles that can contain more than 100 functional proteins, including NOTCH...