BioCentury
ARTICLE | Distillery Therapeutics

Inflammation

March 7, 2018 7:10 PM UTC

Rat studies suggest the generic ADRA2 agonist/COX inhibitor guanabenz could help treat traumatic brain injury (TBI). In a rat model of TBI, intraperitoneal (i.p.) injection of guanabenz 30 minutes post-injury increased the number of neurons expressing the neurogenesis marker doublecortin (DCX) in the ipsilateral hippocampus and increased contextual memory compared with vehicle. Next steps could include testing guanabenz in additional models of TBI models.

Guanabenz is marketed as a generic ADRA2 agonist for hypertension...