BioCentury
ARTICLE | Preclinical News

Targeting IL-30 could treat prostate cancer

March 2, 2018 9:33 PM UTC

In a paper published in Cancer Research, Italian researchers found interleukin-30 (IL-30; IL-27p28) promotes growth and spread of prostate cancer stem-like cells and could be a target for treating the disease.

The researchers, who are based at the University of Chieti-Pescara and the San Raffaele Scientific Institute, first showed exposure to IL-30 increased proliferation and colony and sphere formation of prostate cancer stem-like cells (PCSLCs) isolated from precancerous lesions in a transgenic mouse model of prostate cancer...