A path less traveled
How TNFα could be steered toward an antitumor signaling pathway
A team from PSL Research University has shown how a nitric oxide (NO)-donating compound steers TNFα signaling away from a pro-survival pathway towards one that promotes death in cancer cells. The findings suggest NO-donors could treat tumors that highly express TNFα, whether initially or in response to cytotoxic therapies.
Previous in vivo studies