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A path less traveled

How TNFα could be steered toward an antitumor signaling pathway

A team from PSL Research University has shown how a nitric oxide (NO)-donating compound steers TNFα signaling away from a pro-survival pathway towards one that promotes death in cancer cells. The findings suggest NO-donors could treat tumors that highly express TNFα, whether initially or in response to cytotoxic therapies.

Previous in vivo studies

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