BioCentury
ARTICLE | Translation in Brief

A path less traveled

How TNFα could be steered toward an antitumor signaling pathway

March 1, 2018 3:03 PM UTC

A team from PSL Research University has shown how a nitric oxide (NO)-donating compound steers TNFα signaling away from a pro-survival pathway towards one that promotes death in cancer cells. The findings suggest NO-donors could treat tumors that highly express TNFα, whether initially or in response to cytotoxic therapies.

Previous in vivo studies have demonstrated NO can enable tumors to overcome drug resistance to standard-of-care cytotoxic therapies, though its mechanism of action was unknown. ...