BioCentury
ARTICLE | Preclinical News

Mutant p53 promotes tumor growth via exosomal miR-1246

February 27, 2018 1:16 AM UTC

A new study from the National Institutes of Health suggests mutant p53 promotes cancer progression by creating an immunosuppressive tumor microenvironment, in addition to its known roles inside cancer cells.

p53 is one of the most commonly mutated tumor suppressors in cancer patients. While some mutations lead to loss of the protein, gain-of-function mutations in p53 drive transcriptional changes in cancer cells that promote tumor growth...