BioCentury
ARTICLE | Preclinical News

New fluorination method expands medicinal chemistry toolbox

February 22, 2018 12:13 AM UTC

In a paper published in Nature, a group from the Max Planck Institute and Harvard University describe a method to fluorinate a wider array of aromatic carbon-hydrogen bonds than currently available methods allow. The method could provide drug developers access to a broader range of candidates with enhanced chemical properties.

Fluorination can improve therapeutic compound properties such as metabolic stability, or the ability to cross the blood brain barrier. Currently, carbon-hydrogen fluorination is achieved with unstable, harsh chemicals that require specialized handling, or with mild fluorinating agents that are energetically limited with regards to which carbon-hydrogen bonds they can act on...

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