Cardiovascular

Mouse studies suggest the CysLT1 inhibitor Singulair montelukast could help treat abdominal aortic aneurysm (AAA). In a mouse model of calcium chloride-induced AAA, Singulair decreased aortic dilation compared with no treatment. In a mouse model of angiotensin II-induced aortic rupture, Singulair decreased the rupture rate compared with vehicle. In a mouse model of porcine pancreatic elastase-induced AAA, Singulair decreased abdominal aortic diameter. Next steps could include testing Singulair in AAA patients...