BioCentury
ARTICLE | Preclinical News

HDAC3 inhibition promotes peripheral remyelination

February 12, 2018 4:45 PM UTC

A study published in Nature Medicine identified histone deacetylase 3 (HDAC3) as a target for boosting remyelination in peripheral neuropathies.

Following demyelination in a mouse model of sciatic nerve injury, researchers from Cincinnati Children’s Hospital Medical Center and colleagues showed that tool compound HDAC3 inhibitors increased the number of myelin-producing Schwann cells at the injury site, as well as the number of myelinated axons and thickness of myelin sheaths, compared with vehicle. The compounds also increased action potential conduction and motor function in the mice...