BioCentury
ARTICLE | Tools & Techniques

Synthetic expressions

How synthetic biology could lead to a new generation of gene therapies

January 19, 2018 3:28 AM UTC

Bringing synthetic biology to transcriptional regulation could catalyze a new generation of gene therapies that are more tunable, disease-specific and easy to deliver than the products dominating the field.

The new constructs include synthetic promoters that can optimize expression of vector-encoded genes, and synthetic transcription factors that can activate silent regions of a patient’s own genome. ...