Designing specificity

How C4X Discovery identified its selective OX1R antagonist

Solving a key problem in the orexin field, C4X Discovery Holdings plc (LSE:C4XD) has described how its technology platform yielded an antagonist with selectivity for OX1R over OX2R and disclosed data for the compound in a preclinical model of addiction.

The orexin system consists of two isoforms of orexin (hypocretin; HCRT) -- orexin-A and orexin-B -- that bind the G protein-coupled

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