Chronic neuroprotection

How inhibiting DLK could be neuroprotective in both ALS and AD

Two studies by Genentech have shown DLK inhibition is neuroprotective in two chronic neurodegenerative diseases and suggest the target may play a broad role in driving neurodegeneration, regardless of the underlying cause.

MAP kinase kinase kinase 12 (DLK; MAP3K12) is primarily expressed in neuronal cells, where it plays roles in stress response and neuronal injury. Previous studies showed inhibition of the c-jun

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