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MicroRNA mimics step out of the vehicle and get targeted to tumors

A Purdue University team has developed a ligand-targeted method to deliver microRNA (miRNA) mimics to tumors without relying on vehicles or compromising miRNA processing. The researchers think their folate receptor-targeted miRNAs, or “FolamiRs,” could widen the therapeutic window for miRNA therapies by increasing their stability while allowing them to avoid healthy cells and vehicle-driven toxicity.

Individual miRNAs silence post-transcriptional expression of multiple genes, and

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