Not PGE2's first Rodeo
How Rodeo's HPGD inhibitor could promote tissue regeneration
Rodeo Therapeutics Corp. is boosting prostaglandin E2 production within cells rather than delivering it systemically to promote tissue regeneration without the side effects that have dogged the molecule in the past.
Tissues up-regulate prostaglandin E2 (PGE2) in response to stress or injury to induce proliferation of the local stem cells that can repair them.
Scientific co-founder Sanford Markowitz said although oral PGE2 analogs were once used to treat gastric ulcers based on